GeneSTAR Research Center - Genetic Studies of Atherosclerosis Risk
Welcome to Johns Hopkins GeneSTAR 

In 1982, The Johns Hopkins Sibling and Family Heart Study was created to study patterns of coronary heart disease in high risk families. In 2015, the GeneSTAR Center extends its research to better understanding risk factors, genomics, biological models, and cellular science to better understand the causes of heart disease and stroke. 

Please visit our pages to learn more about our study, investigators,and how to access data for research. 

Heart Disease in in Families

GeneSTAR is a family-based study in initially healthy brothers and sisters, and offspring of people with early onset coronary disease under 60 years of age, The goal is to discover and amplify mechanisms of atherosclerotic vascular diseases and attendant problems such as stroke and circulatory problems

The African American and European American family cohort a have undergone extensive screening, genetic testing, and follow-up for new cardiovascular disease, stroke, and other clinical events for 5 to 32 years.  Currently genetic data consists of a 1 Million genome wide scan, exome chip, and soon, whole genome sequencing as part of the new TOPMed program. We have created pluripotent stem cells that may be used to create new derived cell lines that can be used as models for the study of disease, offering an enormous opportunity for functional studies of genetic findings.

In 2016-2017, the follow-up and health update will occur, as it does every 5 years. We anticipate starting in the summer of 2016.