GeneSTAR Research Center - Genetic Studies of Atherosclerosis Risk
Welcome to Johns Hopkins GeneSTAR 
Division of General Internal Medicine 

In 1982 The Johns Hopkins Sibling and Family Heart Study was created jointly by the Divisions of Internal Medicine and Cardiology  to study patterns of coronary heart disease and related risk factors in high risk families with early-onset coronary disease, identified form 10 Baltimore area Hospitals.. 

The GeneSTAR Center has since grown enormously over 34 years. GeneSTAR now broadly studies various mechanisms of coronary heart disease and stroke using highly novel scientific models and exciting new methods.


GeneSTAR is a family-based study in initially healthy brothers and sisters, and offspring of people with early onset coronary disease under 60 years of age, The goal is to discover and amplify mechanisms of atherosclerotic vascular diseases and the major attendant problems such as stroke and coronary heart disease.

Our African American and European American family cohort has undergone extensive screening, genetic testing, and follow-up for new cardiovascular disease, stroke, and other clinical events for 5 to 32 years.  Currently genetic data consists of a 1 Million genome wide scan, exome chip, and  whole genome sequencing as part of the new NIH TOPMed program. 

In 2017, the health outcomes follow-up and update is being conducted, as ioccurs every 5 years, allowing us to gain data from 5-34 years after participants first entered our study. 

Welcome to GeneSTAR!