GeneSTAR Research Center - Genetic Studies of Atherosclerosis Risk

Phenotypic Variables
 
Detailed information is available on each class of phenotypic variables listed below. The phenotypes range from biomarkers to imaging and detailed incident disease information. 
 
Criteria for adjudicating coronary disease outcomes is available beneath the table on a PDF attachmement.Please inquire for the numbers available for each phenotype as it may vary.  Please address phenotype inquiries to lryanek@jhmi.edu. with a copy to dbecker@jhmi.edu. 
 
 
General Category
Brief List of Phenotypic Variables
 Sociodemographic variables
Age, sex, race (self-report US census codes), marital status, employment status, residence, education
 Medical history
Chronic and acute conditions; symptom check list (acute and chronic); current medications
 Physical examination
Cardiac and chest auscultation, systems examination; xanthomas
 Blood lipid concentrations
Total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol. NMR spectroscopy for particle size, VAP
 Glucose and insulin concentrations
Fasting plasma glucose, fasting insulin; HOMA-IR, QUICKI
 Inflammatory cytokines
hs-CRP, IL-6, IL-1Beta, MMP-9, MCP-1, ICAM, VCAM
 Thrombosis and hemostasis factors
PAI-1, fibrinogen, Lp(a)
 Platelet function
Aggregation, slope and lag time to ADP, epinephrine, collagen, arachidonic acid at different doses, pre and post Aspirin in whole blood and PRP. PFA-100. Urinary thromboxane metabolite. (over 400 platelet function phenotypes)- please inquire for full list
 Blood counts
WBC, RBC, platelet count, hematocrit, hemoglobin, RDW
 Anthropometrics
Waist, height, weight, BMI
 Lifestyle risk factors
Physical activity, diet, smoking
 Vascular properties
Brachial artery reactivity (flow-mediated dilatation), arterial stiffness, carotid distensibility, aortic pulse wave velocity, pulse pressure
 Blood pressure
Resting, post exercise, during exercise
 Peripheral arterial disease
Resting and post exercise ankle brachial blood pressures (ABI); PAD diagnosis
 Coronary artery calcification (CAC)
Helical CT, Agatston Scores
 Coronary CT angiography (with contrast)
Calcified and uncalcified plaque, percent stenosis, plaque volumetrics
 Exercise Stress testing
Maximal symptom limited treadmill testing, MET, exercise electrocardiogram (ischemia). serial blood pressure measurements, post exercise ABI
Exercise nuclear perfusion imaging
Single Photon Emission Tomography (SPECT), using thallium-201 or sestamibi.
 Occult cerebrovascular disease
 Cranial MRA, MRI, white matter disease volumetrics, lacunes, brain volumes, ARIC/CHS visual analogue scores
 Incident cardiovascular and cerebrovascular disease events
Coronary disease  (acute coronary syndromes, stable syndromes), interventions for CAD, stroke, TIA, PAD
 Mental stress. other physiologic stress
Stroop color word test, cold pressor testing, heart rate variability (imited N)
 Psychological factors
General Well-being Schedule (anxiety, depression, somaticism, chronic stress/distress), social support, religiosity, cultural identity (African Americans)
 
Cardiovascular Disease Events Classification Criteria